James Roday ... Shawn SpencerDulé Hill ... Burton Guster "Gus"
Maggie Lawson ... Detective Juliet O'Hara
Timothy Omundson ... Detective Carlton Lasseter
Corbin Bernsen ... Henry Spencer
Kirsten Nelson ... Chief Karen Vick
Guest Stars:
Liam James ... young Shawn (60 episodes)
Kurt Fuller ... Woody the Coroner(16 episodes)
Skyler Gisondo ... young Shawn (10 episodes)
Rachel Leigh Cook ... Abigail Lytar (6 episodes)
William Shatner ... Frank O'Hara (2 episodes)
Chris Sarandon ... Ashton Bonaventure (1 episode)
Ralph Macchio ... Nick Conforth (1 episode)
John Cena ... Ewan O'Hara (1 episode)